Myofascial pain syndrome (MPS) is a common syndrome characterized by chronic pain with high incidence and wide range of patients, which seriously affects the labor efficiency. Physical therapy is often used in clinical treatment for MPS. Low level laser therapy, one of the common physical therapies, has the effect of anti-inflammation, relieving pain and eliminating swelling. In recent years, it has become a new hot field of clinical research on MPS. We reviewed the basic research, laser parameters, and outcome measurements of low level laser therapy for MPS to provide a basis for optimizing the mechanism study, improving clinical therapy, and improving the clinical curative effect.