The objective of the research was to investigate whether high-intensity anthropogenic disturbance changed the profile characteristics of soil salinity in coastal wetlands. Soil samples of different vegetation zones were collected in natural wetland (NW) and anthropogenic disturbance wetland (AW) in the Yellow River Delta, and tested in the laboratory. One-way ANOVA, nonparametric test and cluster analysis were applied for statistical analysis. The results showed that soil salinity ranged from mild salinization to saline soil along the land-sea gradient. Profile characteristics of soil salinity was significantly influenced by human disturbance, varying with plant communities. In general, compared to NW, soil salinization was much heavier in AW. Soil samples were clustered into three profile types: surface accumulation profile (SAP), oscillation profile (OP), even distribution profile (EDP). The profile types ranged from SAP and OP to EDP in spatial pattern from sea to land. The A-CL and bare tidal flat soil samples showed surface accumulative feature with coefficient of surface accumulation of 63%, belonging to SAP. And almost two-thirds of soil samples belonged to EDP. The dam and tarmac construction weakened the tidal connectivity and destroyed wetland habitats (e.g., soil water content, bulk density, etc.) by direct blocking or terrain changes, which could be the main attribution to soil salinization and salt surface accumulation. Thus hydrological connectivity restoration measures, such as sluice regulation and ecological water compensation projects, could be used to improve soil salinization and promote sustainable development of coastal wetlands in the Yellow River Delta.