Journal of Innovative Optical Health Sciences, Volume. 12, Issue 5, 1930004(2019)

Fluorescence lifetime imaging microscopy and its applications in skin cancer diagnosis

Lixin Liu1,*... Qianqian Yang1, Meiling Zhang1, Zhaoqing Wu1 and Ping Xue2 |Show fewer author(s)
Author Affiliations
  • 1School of Physics and Optoelectronic Engineering, Xidian University, Xi'an 710071, P. R. China
  • 2State Key Laboratory of Low-Dimensional Quantum Physics, Department of Physics, Tsinghua University, Beijing 100084, P. R. China
  • show less

    Fluorescence lifetime (FLT) of fluorophores is sensitive to the changes in their surrounding microenvironment, and hence it can quantitatively reveal the physiological characterization of the tissue under investigation. Fluorescence lifetime imaging microscopy (FLIM) provides not only morphological but also functional information of the tissue by producing spatially resolved image of fluorophore lifetime, which can be used as a signature of disorder and/or malignancy in diseased tissues. In this paper, we begin by introducing the basic principle and common detection methods of FLIM. Then the recent advances in the FLIM-based diagnosis of three different skin cancers, including basal cell carcinoma (BCC), squamous cell carcinoma (SCC) and malignant melanoma (MM) are reviewed. Furthermore, the potential advantages of FLIM in skin cancer diagnosis and the challenges that may be faced in the future are prospected.

    Tools

    Get Citation

    Copy Citation Text

    Lixin Liu, Qianqian Yang, Meiling Zhang, Zhaoqing Wu, Ping Xue. Fluorescence lifetime imaging microscopy and its applications in skin cancer diagnosis[J]. Journal of Innovative Optical Health Sciences, 2019, 12(5): 1930004

    Download Citation

    EndNote(RIS)BibTexPlain Text
    Save article for my favorites
    Paper Information

    Received: Mar. 26, 2019

    Accepted: Jun. 10, 2019

    Published Online: Oct. 22, 2019

    The Author Email: Liu Lixin (lxliu@xidian.edu.cn)

    DOI:10.1142/s1793545819300040

    Topics