It is reported that supercontinuum spectrums can be generated in two holey microstructure fibers launched by the 20 fs laser pulse train from a Ti:sapphire laser oscillator.Broadband continua extending from 420 to 980 are obtained in the microstructure with.random air lines. It is found that not only MF with periodical air lines but also MF with random air lines can be used to generate supercontinuum. Analysis indicates that smaller effective mode area and higher nonlinear coefficient are propitious to the supercontinuum generation.