In order to prevent the negative effect of vibration of vehicle-mounted Fourier transform infrared (FTIR) spectrometer produced in the process of movement on the FTIR spectrometer, and ensure signal-to-noise rate and measurement accuracy of the spectrometer, a FTIR spectrometer system combining a structure of angle mirror and a damping system with single degree of freedom is designed to increase the anti-vibration performance of the spectrometer. A series of test experiments about desktop vibration are conducted to validate the good anti-vibration performance of swing angle mirror structure, which proves that damping system of single degree of freedom could significantly increase the anti-vibration performance of spectrometer. Finally, experiments on vehicle-mounted FTIR spectrometer are carried out. Results show that the mean signal-to-noise rate of the spectrum measured in the process of movement reached 94% of that in the static process. The designed system can run smoothly in mobile platform, which has good anti-vibration performance and can provide application conditions for vehicle-mounted monitoring of FTIR spectrometer.