A design method for the digital camera based on a back illuminated 1 024 pixel×1 024 pixel Electron Multiplying(EM)CCD image sensor is proposed. The Complex Programming Logical Device(CPLD) is adopted to generate the CCD driver timing and video processing timing, EL7156C pin driver chip is used for standard EMCCD clocks, and a discrete circuit is used for EM clock. By adopting a CCD analog front-end chip VSP2566 with Correlation Double Sampling(CDS) function to sample, the image data of the CCD output are digitized. The design methods of logic timing control, driver circuit, and video processing circuit are introduced. Experiments show that the digital camera circuit can output 16 bit digital image data simultaneously at a speed of 8 frame/s, its optical dynamic range can exceed 70 dB, and the remote programmable control electron multiplication can operate at the gain more than 50 dB. The design has been used in the remote EMCCD imaging system, and also can be applied to the low light level imaging area and radiation diagnosis field.