Through the simulation of laminated plate irradiated by laser, the distribution of stress and strain is found. Firstly, temperature field is gotten through numerical simulation, and then the thermal stress and strain are obtained by inputting the temperature field to the analysis model. The result shows that stress along the fiber decreases after the transition from the maximum tensile stress at the center point to the minimum compressive stress at the point about 5 mm away from the edge of the laser spot; stress perpendicular to the fiber is always compressive stress in the laser spot and the surrounding area; Mises stress reaches the maximum at the center point and decreases with the increase of the distance to the center point. Thermal strike causes the fluctuation, and the larger the laser intensity, the earlier the fluctuation happens. In order to verify the numerical model, the strain gauges are stuck around the laser spot on the front face of laminated plate under laser irradiation. The strains of the points are tested with dynamic strain instrument. The strain of simulation coincides with experiment nicely, the maximum relative error is 18.4% between the simulation and experiment results.