With the characteristics of femtosecond laser ultrashort pulse and high peak power, cutting processing of nonmetal vascular shent is studied. Experiments show that using femtosecond laser can achieve precision machining without thermal damage. The relationship between parameters of machining non metallic stent is obtained through orthogonal experiment, and the optimum processing parameters are obtained: laser pulse frequency is 10 kHz, pulse width is 412 fs, laser power is 1.6 W, the auxiliary Ar pressure is 0.8 MPa, cutting speed is 1.2 mm/s. The processing of nonmetal material polylactic acid has the effect of tangent fine flat, cutting edge smooth, no surface carbonization residue. High quality non-metallic stent sample is obtained.