In order to make the Opt-Mec design meet the requirements of imagine systems, the impact of mechanical vibration on the Modulation Transfer Funtion(MTF) is analyzed. By considering the form of optical imaging system to vibration and taking the MTF as an evaluation function, this paper quantitatively analyzes the impacts of various forms of mechanical vibration on image resolution and discusses the influence of each kind of parameter on the MTF based on the knife-edge theory (Line Spread Function,LSF). These analysises provide theory basis for the intensity, rigidity and the precision design of optics machinery. Combining engineering practice, several kinds of schemes are proposed to reduce the impact of vibration on the imaging quality. Through the MTF analysis for a imaging equipment, the dynamic resolution of 22 lp/mm for a imaging equipmen is obtained,which is close to the actual photograph result. The results indicate that the analysis is correct and usable.