A method of calibration based on accurate Infrared standard stars was proposed for increasing infrared radiation measurement precision.By measuring a series of Infrared calibration stars at different air masses,the infrared radiation responsivity of measurement system and atmospheric extinction can be obtained simultaneously.The data were reduced with astronomical aperture photometry and least-squares fitting according to more thorough atmospheric extinction models.Validation experiments on the 1.2 m telescope′s infrared imaging terminal for the proposed method indicated that the maximum error of stellar irradiance inversion was 16.28%.Without additional calibration device,the proposed calibration method is simple and easy to implement.Real-time calibration of the telescope could be realized at any time.The proposed calibration method has important application value for infrared radiometry of large aperture ground-based telescopes.