The editorial provides a retrospective glance at the first six months of publication, with a bright forecast for the year ahead.

Photoacoustic imaging (PAI), recognized as a promising biomedical imaging modality for preclinical and clinical studies, uniquely combines the advantages of optical and ultrasound imaging. Despite PAI’s great potential to provide valuable biological information, its wide application has been hindered by technical limitations, such as hardware restrictions or lack of the biometric information required for image reconstruction. We first analyze the limitations of PAI and categorize them by seven key challenges: limited detection, low-dosage light delivery, inaccurate quantification, limited numerical reconstruction, tissue heterogeneity, imperfect image segmentation/classification, and others. Then, because deep learning (DL) has increasingly demonstrated its ability to overcome the physical limitations of imaging modalities, we review DL studies from the past five years that address each of the seven challenges in PAI. Finally, we discuss the promise of future research directions in DL-enhanced PAI.

The photosensitivity of silicon is inherently very low in the visible electromagnetic spectrum, and it drops rapidly beyond 800 nm in near-infrared wavelengths. We have experimentally demonstrated a technique utilizing photon-trapping surface structures to show a prodigious improvement of photoabsorption in 1-μm-thin silicon, surpassing the inherent absorption efficiency of gallium arsenide for a broad spectrum. The photon-trapping structures allow the bending of normally incident light by almost 90 deg to transform into laterally propagating modes along the silicon plane. Consequently, the propagation length of light increases, contributing to more than one order of magnitude improvement in absorption efficiency in photodetectors. This high-absorption phenomenon is explained by finite-difference time-domain analysis, where we show an enhanced photon density of states while substantially reducing the optical group velocity of light compared to silicon without photon-trapping structures, leading to significantly enhanced light–matter interactions. Our simulations also predict an enhanced absorption efficiency of photodetectors designed using 30- and 100-nm silicon thin films that are compatible with CMOS electronics. Despite a very thin absorption layer, such photon-trapping structures can enable high-efficiency and high-speed photodetectors needed in ultrafast computer networks, data communication, and imaging systems, with the potential to revolutionize on-chip logic and optoelectronic integration.

Metasurfaces have emerged as a flexible platform for shaping the electromagnetic field via the tailoring phase, amplitude, and polarization at will. However, the chromatic aberration inherited from building blocks’ diffractive nature plagues them when used in many practical applications. Current solutions for eliminating chromatic aberration usually rely on searching through many meta-atoms to seek designs that satisfy both phase and phase dispersion preconditions, inevitably leading to intensive design efforts. Moreover, most schemes are commonly valid for incidence with a specific spin state. Here, inspired by the Rayleigh criterion for spot resolution, we present a design principle for broadband achromatic and polarization-insensitive metalenses using two sets of anisotropic nanofins based on phase change material Ge2Sb2Se4Te1. By limiting the rotation angles of all nanofins to either 0 deg or 90 deg, the metalens with a suitable numerical aperture constructed by this fashion allows for achromatic and polarization-insensitive performance across the wavelength range of 4–5 μm, while maintaining high focusing efficiency and diffraction-limited performance. We also demonstrate the versatility of our approach by successfully implementing the generation of broadband achromatic and polarization-insensitive focusing optical vortex. This work represents a major advance in achromatic metalenses and may find more applications in compact and chip-scale devices.

On-chip focusing of plasmons in graded-index lenses is important for imaging, lithography, signal processing, and optical interconnects at the deep subwavelength nanoscale. However, owing to the inherent strong wavelength dispersion of plasmonic materials, the on-chip focusing of plasmons suffers from severe chromatic aberrations. With the well-established planar dielectric grating, a graded-index waveguide array lens (GIWAL) is proposed to support the excitation and propagation of acoustic graphene plasmon polaritons (AGPPs) and to achieve the achromatic on-chip focusing of the AGPPs with a focus as small as about 2% of the operating wavelength in the frequency band from 10 to 20 THz, benefiting from the wavelength-independent index profile of the GIWAL. An analytical theory is provided to understand the on-chip focusing of the AGPPs and other beam evolution behaviors, such as self-focusing, self-collimation, and pendulum effects of Gaussian beams as well as spatial inversions of digital optical signals. Furthermore, the possibility of the GIWAL to invert spatially broadband digital optical signals is demonstrated, indicating the potential value of the GIWAL in broadband digital communication and signal processing.

Electron–phonon coupling can tailor electronic transition processes and result in direct lasing far beyond the fluorescence spectrum. The applicable time scales of these kinds of multiphonon-assisted lasers determine their scientific boundaries and further developments, since the response speed of lattice vibrations is much slower than that of electrons. At present, the temporal dynamic behavior of multiphonon-assisted lasers has not yet been explored. Herein, we investigate the Q-switched laser performance of ytterbium-doped YCa4O(BO3)3 (Yb:YCOB) crystal with phonon-assisted emission in nanosecond scales. Using different Q-switchers, the three-phonon-assisted lasers around 1130 nm were realized, and a stable Q-switching was realized in the time domain from submicroseconds to tens of nanoseconds. To the best of our knowledge, this is the longest laser wavelength in all pulse Yb lasers. The minimum pulse width and maximum pulse energy are 29 ns and 204 μJ, respectively. These results identify that the electron–phonon coupling is a fast physical process, at least much faster than the present nanosecond pulse width, which supports the operation of multiphonon-assisted lasers in the nanosecond range. In addition, we also provide a simple setup to create pulse lasers at those wavelengths with weak spontaneous emission.

One-dimensional Airy beams allow the generation of thin light-sheets without scanning, simplifying the complex optical arrangements of light-sheet microscopes (LSMs) with an extended field of view (FOV). However, their uniaxial acceleration limits the maximum numerical aperture of the detection objective in order to keep both the active and inactive axes within the depth of field. This problem is particularly pronounced in miniaturized LSM implementations, such as those for endomicroscopy or multi-photon neural imaging in freely moving animals using head-mounted miniscopes. We propose a new method to generate a static Airy light-sheet with biaxial acceleration, based on a novel phase profile. This light-sheet has the geometry of a spherical shell whose radius of curvature can be designed to match the field curvature of the micro-objective. We present an analytical model for the analysis of the light-sheet parameters and verify it by numerical simulations in the paraxial regime. We also discuss a micro-optical experimental implementation combining gradient-index optics with a 3D-nanoprinted, fully refractive phase plate. The results confirm that we are able to match detection curvatures with radii in the range of 1.5 to 2 mm.

A wideband sensitive needle ultrasound sensor based on a polarized PVDF-TrFE copolymer piezoelectric film has been developed, which is capable of providing a noise equivalent pressure of 14 Pa and a uniform frequency response ranging from 1 to 25 MHz. Its high sensitivity (1.6 μV / Pa) and compact size were achieved by capitalizing on the large electromechanical coupling coefficient of PVDF-TrFE and minimizing parasitic capacitance in a two-stage amplifier structure. The detection sensitivity of the newly designed sensor outperformed commercially available hydrophones with an equivalent sensing element area by a factor of 9. The sensor has been successfully integrated into a light scanning optoacoustic microscopy (OAM) system with a limited working space. Submicrometer resolution images were subsequently attained from living mice without employing signal averaging. The miniature sensor design can readily be integrated into various OAM systems and further facilitate multimodal imaging system implementations.

Imaging through multimode fiber (MMF) provides high-resolution imaging through a fiber with cross section down to tens of micrometers. It requires interferometry to measure the full transmission matrix (TM), leading to the drawbacks of complicated experimental setup and phase instability. Reference-less TM retrieval is a promising robust solution that avoids interferometry, since it recovers the TM from intensity-only measurements. However, the long computational time and failure of 3D focusing still limit its application in MMF imaging. We propose an efficient reference-less TM retrieval method by developing a nonlinear optimization algorithm based on fast Fourier transform (FFT). Furthermore, we develop an algorithm to correct the phase offset error of retrieved TM using defocused intensity images and hence achieve 3D focusing. The proposed method is validated by both simulations and experiments. The FFT-based TM retrieval algorithm achieves orders of magnitude of speedup in computational time and recovers 2286 × 8192 TM of a 0.22 NA and 50 μm diameter MMF with 112.9 s by a computer of 32 CPU cores. With the advantages of efficiency and correction of phase offset, our method paves the way for the application of reference-less TM retrieval in not only MMF imaging but also broader applications requiring TM calibration.

Structured illumination-based super-resolution Förster resonance energy transfer microscopy (SIM-FRET) provides an approach to resolving molecular behavior localized in intricate biological structures in living cells. However, SIM reconstruction artifacts will decrease the quantitative analysis fidelity of SIM-FRET signals. To address these issues, we have developed a method called HiFi spectrum optimization SIM-FRET (HiFi-SO-SIM-FRET), which uses optimized Wiener parameters in the two-step spectrum optimization to suppress sidelobe artifacts and achieve super-resolution quantitative SIM-FRET. We validated our method by demonstrating its ability to reduce reconstruction artifacts while maintaining the accuracy of FRET signals in both simulated FRET models and live-cell FRET-standard construct samples. In summary, HiFi-SO-SIM-FRET provides a promising solution for achieving high spatial resolution and reducing SIM reconstruction artifacts in quantitative FRET imaging.

Laser processing with high-power ultrashort pulses, which promises high precision and efficiency, is an emerging new tool for material structuring. High repetition rate ultrafast laser highlighting with a higher degree of freedom in its burst mode is believed to be able to create micro/nanostructures with even more variety, which is promising for electrochemical applications. We employ a homemade high repetition rate ultrafast fiber laser for structuring metal nickel (Ni) and thus preparing electrocatalysts for hydrogen evolution reaction (HER) for the first time, we believe. Different processing parameters are designed to create three groups of samples with different micro/nanostructures. The various micro/nanostructures not only increase the surface area of the Ni electrode but also regulate local electric field and help discharge hydrogen bubbles, which offer more favorable conditions for HER. All groups of the laser-structured Ni exhibit enhanced electrocatalytic activity for HER in the alkaline solution. Electrochemical measurements demonstrate that the overpotential at 10 mA cm - 2 can be decreased as much as 182 mV compared with the overpotential of the untreated Ni (-457 mV versus RHE).